Blood and Genomics Discovery Open Access

The Blood and Genomics Discovery (the successor of Asia-Pacific Journal of Blood Types and Genes), a peer-reviewed open access publication, intends to provide the researchers and clinicians in the globe with an open forum to disseminate important new information in aspects of experimental, translational and clinical medicine of blood diseases and blood transfusion, and genomics research on blood,etc.

Blood and Genomics Discovery

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Articles (1) All articles

Communication

08 October 2024

Alterations of T Cell Subsets Associated with Sickle Cell Trait

Sickle cell trait (SCT) has been associated with alterations in various immune-related laboratory parameters including lower circulating lymphocyte counts. To further characterize the impact of SCT on the immune system, we performed flow cytometry of monocyte and lymphocyte immune cell subsets from peripheral blood mononuclear cells collected in a large, community-based cohort of SCT-positive (n = 68) and SCT-negative (n = 959) Black adults. SCT was significantly associated with lower proportions of CD8⁺and CD4⁺ T cell subsets that include senescent-like markers of repeated immune system challenges. These immune alterations could have potential implications for the susceptibility of individuals with SCT to various infectious diseases.

Alexander P. Reiner*

Laura M. Raffield

Margaret F. Doyle

Communication

08 October 2024

Alterations of T Cell Subsets Associated with Sickle Cell Trait

Sickle cell trait (SCT) has been associated with alterations in various immune-related laboratory parameters including lower circulating lymphocyte counts. To further characterize the impact of SCT on the immune system, we performed flow cytometry of monocyte and lymphocyte immune cell subsets from peripheral blood mononuclear cells collected in a large, community-based cohort of SCT-positive (n = 68) and SCT-negative (n = 959) Black adults. SCT was significantly associated with lower proportions of CD8⁺and CD4⁺ T cell subsets that include senescent-like markers of repeated immune system challenges. These immune alterations could have potential implications for the susceptibility of individuals with SCT to various infectious diseases.

Alexander P. Reiner

Laura M. Raffield

Lynette Ekunwe

Nels C. Olson

Paul L. Auer

Margaret F. Doyle

Communication

08 October 2024

Alterations of T Cell Subsets Associated with Sickle Cell Trait

Sickle cell trait (SCT) has been associated with alterations in various immune-related laboratory parameters including lower circulating lymphocyte counts. To further characterize the impact of SCT on the immune system, we performed flow cytometry of monocyte and lymphocyte immune cell subsets from peripheral blood mononuclear cells collected in a large, community-based cohort of SCT-positive (n = 68) and SCT-negative (n = 959) Black adults. SCT was significantly associated with lower proportions of CD8⁺and CD4⁺ T cell subsets that include senescent-like markers of repeated immune system challenges. These immune alterations could have potential implications for the susceptibility of individuals with SCT to various infectious diseases.utf-8

Alexander P. Reiner

Laura M. Raffield

Lynette Ekunwe

Nels C. Olson

Paul L. Auer

Margaret F. Doyle

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