Artiles
Review
12 October 2023New Trends on Photoswitchable Antibiotics: From Syntheses to Applications
Antibiotics are excreted in the environment after being used to treat bacterial infections in human and animals. These residues are poorly eliminated by the actual wastewater treatment processes, affecting animal, human and environmental health. This has led to the emergence of antibiotic resistance in bacterial pathogens. To combat this problem, photopharmacology has emerged in the last decades. This approach, based on the coupling of a drug with a photochromic component, is a promising way to control antibiotic activity by light irradiation and consequently limit antibioresistance. Thus, this review summarizes the study on the effect of the irradiation light on the antimicrobial activity of coupling compounds.
Article
12 October 2023Risk Analysis of Crisis Management on the Example of Rural Areas in Poland
The aim of this article is to analyze and assess the risk of crisis hazards and to introduce possible improvements on the example of the Municipality of Branice. The types of threats and the consequences associated with their occurrence are also described. The quality management method (FMEA) was used to develop the risk assessment, as well as an indication of the risk values presented by the risk matrix made. Thanks to the research part of the study, the most probable possible risks and their consequences were detected, and improvements were proposed to prevent the occurrence of such situations in the future. The main conclusions of the study are: (1) a properly prepared crisis management plan is the most important and effective method to deal with emergencies that threaten the life and health of citizens; (2) hazards have been, are, and will continue to accompany people, so adequate preparation is needed to minimize their effects or even eliminate them altogether; (3) during the occurrence of an emergency, the sphere of logistical action is very broad and determines the methods and actions of the relevant services in order to reduce the effects of the threats that occur; (4) the conducted analysis of threats possible to occur in the area of Branice Commune indicates that the highest probability of occurrence of a threat is floods and waterlogging as well as hurricanes and strong winds; (5) the conducted FMEA analysis indicates that a very important factor preventing the creation of the threats discussed in the point above are periodical inspections and cleaning or modernization works of the given threat areas. In summary, the FMEA analysis showed that in the analysed municipality, the most serious risks were flooding and flooding, as well as hurricanes and high winds. The following remedial actions are proposed in the analysis and to improve these areas in the rural areas: water surge in the riverbed (cleaning of the riverbed; repair of dikes; securing roads and communication bridges against possible damage; securing drinking water reservoirs against pollution; securing sewage treatment plants against possible leakage of faecal matter into flood waters); obstruction of field drainage (regular mowing and cleaning of ditches; checking the patency of ditches; roofs of residential and commercial buildings and fallen trees in villages close to houses (inspections and pruning of dangerous tree branches and possible removal of trees threatening danger of falling; inspection of roof structures by building supervision) and fallen trees in riverbeds (cleaning of banks and riverbeds; inspection of tree stands near rivers). The policy implications of this study may be far-reaching, not least because it may determine rural managers to change their management and attention to and response to crisis threats that may occur in such areas. Regarding the limitations of the study, it is important to remember that it was conducted on the author’s chosen terrain. In most cases, changes in the terrain, the population or its management have a determining influence on the shaping of emergency response principles. Therefore, the study conducted should provide an overview of the research issue undertaken. In the future, it is planned to extend the study area to equal rural areas occurring in the world, and it is also planned to verify the existing hazards on the ground on a continuous basis. In addition, it is intended to extend the deeper cooperation with both the rural authorities and the rescue units in order to imply the research results in the actual territorial units.
Article
11 October 2023Fibrous SiC-based Mesoporous Solids for the Photocatalytic Degradation of Organic Pollutants under Artificial Light
SiC-based mesoporous solids with fibrous nanostructure were prepared by impregnation of a polycarbosilane precursor on annealed polyacrylonitrile (PAN) fibers and subsequent pyrolysis. The obtained material exhibits a mesoporous structure and has a specific surface area of ~20 m2/g. It has a semiconducting electronic character with a bandgap of 2.65 eV, i.e., in the visible range. Adsorption tests of methylene blue were performed on the material under dark conditions, which showed an adsorption amount of 78 wt%. The photocatalytic activity of the material was then evaluated for the degradation of the dye under artificial daylight irradiation over a period of 7 h. A degradation of 94 wt% was achieved. Regeneration and reuse of the material was also tested and resulted in 97 wt% degradation after reuse, indicating potential interest of the material as a contactor in environmental remediation devices.
Article
10 October 2023ℒ1 Adaptive Control of Quadrotor UAVs in Case of Inversion of the Torque Direction
This paper presents a method for fault tolerant control of quadrotor UAVs in case of inversion of the torque direction, a situation that might occur due to structural, hardware or software issues. The proposed design is based on multiple-model ℒ1 adaptive control. The controller is composed of a nominal reference model and a set of degraded reference models. The nominal model is that with desired dynamics that are optimal regarding some specific criteria. In a degraded model, the performance criteria are reduced. It is designed to ensure system robustness in the presence of critical failures. The controller is tested in simulations and it is shown that the multiple model ℒ1 adaptive controller stabilizes the system in case of inversion of the control input, while the ℒ1 adaptive controller with a single nominal model fails.
Article
07 October 2023Comprehensive Evaluation of Sustainable Treatment Technology of Oily Sludge Based on AHP-FCE
Oil is an unsustainable energy since it is non-renewable. However, oil may not be completely replaced in a short time, so the environmental problems caused by the oil development still require our attention. The oily sludge is a kind of hazardous waste produced during the oil development. To reduce the environmental impact caused by oily sludge, low-carbon and sustainable treatment technologies need to be selected. The incineration, chemical extraction and thermal desorption are common technologies for treatment of oily sludge. We calculated the carbon emissions of these technologies. Then the index evaluation system of oily sludge treatment technology was established with the environmental, economic, social, and technical factors. And the weight of evaluation index was determined by the analytic hierarchy process (AHP). Through the investigation of industry experts, we evaluated the treatment technologies by the fuzzy comprehensive evaluation method (FCE). The results showed that the carbon emissions of incineration are 42.70 t CO2-eq/t which is the highest. Meanwhile, it is 4.80 t CO2-eq/t and 0.10 t CO2-eq/t for chemical extraction and thermal desorption, respectively. The comprehensive scores of incineration, chemical extraction and thermal desorption were 4.59, 5.16 and 4.95, respectively. Therefore, the chemical extraction technology is an optimal treatment technology for oily sludge with the relatively low carbon emission and the highest comprehensive technical score. At the same time, the thermal desorption technology has strong application potential with the lowest carbon emissions. This result provides a reference for achieving clean and sustainable energy development processes.
Article
25 September 2023Depopulation Villages in Poland—Current Status and Possible Transition Scenarios
The picture of many localities undergoing depopulation will change in the coming years. A significant scale of migration and advanced ageing processes will result in an increase in the number of vacant buildings, or the removal of social infrastructure. The term ‘shrinkage’ tends to have negative connotations, but can lead to positive changes, e.g., an improvement in land structure under conditions of fragmented, dispersed agriculture. Depending on the quality of the natural environment and communication accessibility, other functions will develop there, including housing and recreation. However, a large part of the village may disappear completely.
Article
25 September 2023Anion Exchange Membrane Reinforced with Polyethylene Substrate for Alkaline Fuel Cell Applications
To enhance mechanical robustness of our in-house anion exchange membrane (QPAF-4), the reinforcement technique was applied using ozone-treated, porous polyethylene (PE) thin film (Toray SETELA) as a substrate. Homogenous and flexible reinforced membranes (QPAF-4-PE, 15–20 µm thick) were obtained by bar-coating method. The cross-sectional SEM image and EDS analysis revealed triple-layered (sandwich-like) structure without detectable pinholes. The QPAF-4-PE with ion exchange capacity (IEC) of 1.48 meq·g−1 exhibited lower water uptake (15 wt% at 90% relative humidity) and slightly lower hydroxide ion conductivity (71 mS·cm−1 at 80 ℃) than those of the pristine QPAF-4 (IEC = 1.84 meq·g−1, 25 wt% water uptake and 82 mS·cm−1 of the conductivity). The reinforced QPAF-4-PE exhibited slightly higher viscoelasticity (particularly, in MD direction) due to the suppressed water absorbability. Furthermore, the elongation at break increased by 9.8% in TD direction and 6.3% in MD direction. An H2/O2 fuel cell using QPAF-4-PE as membrane was investigated at different back-pressure, in which the cell with 100 kPa back-pressure onto the cathode side only achieved the maximum performance (176 mW·cm−2 at current density of 364 mA·cm−2) and the longest durability for (>200 h) at a constant current density of 100 mA·cm−2 maintaining 0.43 V of the cell voltage (67% remaining). The durability was eight times longer than that with ambient pressure and two times longer than that with back-pressure on both sides.
Article
19 September 2023Advancing Green Hydrogen Production in Saudi Arabia: Harnessing Solar Energy and Seawater Electrolysis
The transition to clean and sustainable energy sources is crucial for combating the challenges posed by climate change. Green hydrogen, produced through renewable energy-driven electrolysis, holds significant promise as a viable clean energy carrier. The study introduces a system that leverages abundant solar energy and utilizes seawater as the feedstock for electrolysis, potentially offering a cost-effective solution. A comprehensive mathematical model, implemented in MATLAB, is employed to simulate the design and operational efficiency of the proposed green hydrogen production system. The system’s core components include solar panels as a clean energy source, an advanced MPPT charge controller ensuring optimal power delivery to the electrolyzer, and a seawater tank serving as the electrolyte source. The model combines these elements, allowing for continuous operation and efficient hydrogen production, addressing concerns about energy losses and cost-effectiveness. Results demonstrate the influence of solar irradiance on the system’s performance, revealing the need to account for seasonal variations when designing green hydrogen production facilities. Theoretical experiments are conducted to evaluate the behavior of a lithium battery, essential for stabilizing the system’s output and ensuring continuous operation during periods of low solar radiation.
Article
16 September 2023Hepatic Lysosomal Enzyme Activity in Primary Biliary Cholangitis
Background: Lysosomal enzymes are implicated in autophagy and senescence. Hepatic lysosomal enzymes have not been studied in Primary Biliary Cholangitis (PBC). We therefore quantified the activities of lysosomal hydrolases in liver tissue of PBC patients. Methods: We compared enzyme activities in liver tissue from PBC patients with normal livers. Alcoholic liver disease and chronic viral disease served as disease controls. Results: Cathepsin B1 was significantly increased in early PBC (225.1 ± 18.06 mean ± SD, p < 0.0001) and reduced in later stages (66.5 ± 9.7, p = 0.004, controls 130.4 ± 14.9). It was reduced in patients with extensive fibrosis such as alcoholic and viral cirrhosis (p < 0.01 and p = 0.004 respectively) but not in chronic hepatitis. Cathepsin D was increased in early PBC (39 × 103 ± 4.8 SD, p < 0.0001) and less so in later stages (20.1 × 103 ± 3.9, p = 0.05, controls 14.1 × 103 ± 2.9). It was also increased in the presence of histological necro-inflammation in hepatitis. Treatment with ursodeoxycholate (UDCA) restored the abnormal values of enzymes in PBC. Lipid hydrolases mostly paralleled the changes of Cathepsins. Sequential measurements in serum of patients with acute alcoholic hepatitis showed that cathepsin B1 gradually decreases, and esterases increase as aminotransferases improve. Conclusions: The increased activity of lysosomal enzymes in early PBC are possibly on line with increased senescence. Treatment with UDCA restores abnormal values. In chronic liver disease, Cathepsin B1 reduction is associated with fibrosis and increased cathepsin D with necro-inflammation. Abnormalities of lysosomal enzymes indicate impairment of the final stage of autophagy in chronic liver disease.
Commentary
14 September 2023Synthetic Biology Industry in China: Current State and Future Prospects
In this article, we provided an overview of the current state of the SynBio industry in China with a focus on its research and technology, its main applications, and major players. We also discussed future prospects including the challenges and advantages of the SynBio industry in China.
