Artiles
Open Access
Review
27 January 2026Emergent Superorganisms: Grass Rings Shaped by Individual Growth and Mortality
The grass ring phenomenon remains an interesting and enduring puzzle. Previous research has proposed various mechanisms, including Environmental stress and physical disturbance, Nutrient and water depletion, and the Self-Organization hypothesis, to explain ring formation. However, this process is highly complex and dynamic, hindering the development of a unified theory. This is primarily because grass rings of different origins, and even those at different developmental stages, are influenced by diverse factors. Furthermore, existing studies have often been limited to isolated cases, which highlights the need for more comprehensive, global-scale studies. Through a systematic analysis of publications, this review proposes three claims. First, they are classified based on genetic origin into single and multiple individual origins, which align with formation driven primarily by death-based and growth-based formation modes, respectively. Second, the grass ring is essentially a superorganism. Third, although grass rings are globally widespread, their formation mechanisms in regions above 4000 m remain elusive. Future research should prioritize key directions, including quantifying complete life cycles and elucidating mechanisms of high-altitude formation. This requires establishing international monitoring networks that integrate multi-omics with hyperspectral remote sensing to predict how grass rings develop under global climate change.
Open Access
Article
26 January 2026Enhanced Stability of Nickel Phyllosilicate Anchored Ni/SiO2 Catalyst for Liquid-Phase Hydrogenation and Hydrodeoxygenation
The aggregation and leaching of nanoparticles often reduce catalytic activity and hinder the long-term application of catalysts. Here, we synthesis a hollow Ni/SiO2-AEH catalyst with small Ni nanoparticles (NPs) encapsulated by nickel phyllosilicate (NiPS) via an ammonia evaporation-hydrothermal method. Compared with the Ni/SiO2-AE only synthesized via ammonia evaporation method, the Ni/SiO2-AEH catalyst after further hydrothermal treatment possesses more nickel phyllosilicate (NiPS) species, which enhances the stability of Ni NPs through the strong metal-support bonding (Si–O–Ni) in NiPS. By controlling the size of Ni NPs to 3.6 nm along with the presence of NiPS, we find that Ni/SiO2-AEH displays superior catalytic performance for maleic anhydride (MA) hydrogenation and vanillin hydrodeoxygenation, achieving yields of 97% for succinic anhydride (SA) and 99% for 2-methoxy-4-methylphenol (MMP), respectively. Importantly, the deactivation of Ni/SiO2-AEH is remarkably suppressed, with only a slight decrease in activity after five or six runs. The excellent catalytic activity and stability of phyllosilicate materials imply an extensive application in other industrial catalytic reactions.
Open Access
Review
26 January 2026Data Caring While Caring for Human Remains: Challenges of Legacy Collections
Museum collections are essential for scientific research and are diverse in nature. They include human remains and associated information. Many experience discomfort due to historical legacies and procurement practices that are often not openly discussed, which, in an age that advocates Open Science, need open discussion. Within Open Science, open Data Sharing and the FAIR principles (Findable, Accessible, Interoperable, and Reusable) are key guidelines for research data decisions—emphasizing “as open as possible, as closed as necessary”. This manuscript explores how data management and Open Science practices may impact on human ancestral remains, risking perpetuating practices of human remains objectification, reinforcing historical violence through digital means, if not balanced with restrictive access protocols. There is a growing concern for data care and stewardship amongst museums and allied institutions, and although the argument is based on the fairness of sharing and conscious, ethical sharing, source collection and associated data need to be questioned at its origins. Hence, the emphasis is placed on CARE principles (Collective Benefit, Authority to Control, Responsibility, Ethics) prioritising dignity, sovereignty, relationality, and ethics, moving from data accumulation and universal openness toward context-driven, community-controlled, and ethically reflexive stewardship. This approach advocates restraint, challenging museums, researchers, and funders to reconsider the objectification of ancestors and the ethical responsibilities surrounding their digital and material legacies. Ethical issues no longer relate solely to ancestral remains; they extend to their data and metadata across matters related to governance, circulation, “ownership?”, and repatriation. Alongside FAIR, one must practice CARE, and above all, allow for detachment and critical thinking.
Open Access
Review
26 January 2026Synergistic Natural Products in Anti-Ageing: Mechanistic Insights, Experimental Evidence, and Translational Perspectives
Ageing is characterised by a progressive decline in physiological function driven by oxidative stress, chronic inflammation, and metabolic imbalance. Natural products contain diverse bioactive compounds capable of regulating these interconnected processes through convergent molecular pathways. This review synthesises current evidence across six major classes of natural bioactives, including polyphenols, terpenoids, polyamines, polysaccharides, fatty acids, and bioactive peptides, and examines their roles within metabolic, redox, inflammatory, and epigenetic networks. Individually, these compounds enhance mitochondrial function, modulate AMP-activated protein kinase (AMPK)–sirtuin 1 (SIRT1)–mechanistic target of rapamycin complex 1 (mTORC1) signalling, activate the nuclear factor erythroid 2-related factor 2 (Nrf2)–antioxidant response element (ARE) antioxidant pathway, suppress nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) activation, and improve cellular stress resilience. When used in combination, they exhibit synergistic interactions that amplify antioxidant, anti-inflammatory, and metabolic benefits, resulting in measurable improvements in lifespan and healthspan. Quantitative analyses demonstrate that rationally designed combinations achieve approximately 20–35 percent greater efficacy than single agents, reflecting coordinated multi-target reinforcement rather than simple additive effects. Overall, these insights highlight the mechanistic rationale, experimental evidence, and translational potential of synergistic natural bioactives as promising strategies for promoting healthy ageing and mitigating age-related decline.
Open Access
Article
26 January 2026Investigating the Interplay of Springshed Phenomenon and Its Crucial Role in Fostering Sustainable Practices and Community Resilience: Reflection from the Indian Himalayan Regions
This study examines the critical role of springsheds in fostering resilient communities and sustainable practices in the Indian Himalayan regions, focusing on Kalimpong I (Kalimpong) and Bhurung (Sikkim). The research addresses the pressing environmental challenges, particularly resource depletion and water scarcity, that threaten these ecologically sensitive areas. By integrating physical, environmental, and socio-economic analyses, the study compares the spring water quality, utility, and mobility in the two springsheds. It also identifies obstacles residents face in accessing these water sources. Utilizing mixed methods, including field surveys, in-depth interviews, GIS-based mapping, and water quality analysis, the study reveals the indispensable role of springs in daily life, providing essential water for drinking, agriculture, and domestic use. The findings emphasize the need to integrate traditional knowledge with sustainable practices, such as rainwater harvesting and afforestation, to enhance community resilience. This research highlights the importance of community-driven approaches to environmental sustainability, offering valuable insights for similar ecological settings worldwide.
Open Access
Article
22 January 2026Therapies Targeting Metabolic Pathways in Lung Fibrosis: Advances and Future Perspectives
Pulmonary fibrosis is a progressive lung disease associated with high morbidity and mortality. Increasing evidence indicates that metabolic reprogramming is a central driver of fibrogenesis. Multiple cell types in the fibrotic lung, including fibroblasts, alveolar epithelial type II (AEC2) cells, and macrophages, exhibit enhanced glycolysis, dysregulated lipid turnover, and altered amino acid utilization. These metabolic changes promote fibroblast activation, sustain ECM production, and impair epithelial repair. Recent studies have identified key regulatory pathways—such as hypoxia-inducible factor-1α(HIF-1α)-mediated glycolysis, aberrant fatty acid and cholesterol metabolism, and glutamine-dependent anabolic processes—that collectively shape the profibrotic microenvironment. Targeting these metabolic vulnerabilities has shown promising antifibrotic effects in preclinical studies, supporting glycolysis inhibitors, lipid-modulating agents, and amino acid metabolism blockers as potential therapeutic approaches. This review summarizes recent advances in glucose, lipid, and amino acid metabolic reprogramming in pulmonary fibrosis, with IPF discussed as a representative and well-studied subtype, and highlights emerging metabolic-targeted therapeutic strategies. Understanding cell-specific metabolic adaptations may provide new opportunities to develop effective interventions for pulmonary fibrosis, whereas most metabolic mechanisms are shared across fibrotic lung diseases.
Open Access
Article
21 January 2026Milling Mechanism of Sheet Fiberglass Plastic by a Tungsten Carbide Tool with Diamond and Diamond-like Wear-Resistant Coatings
The study focuses on identifying the specific mechanisms of the FR4 fiberglass composite milling process using tungsten carbide end mills with wear-resistant diamond-like and diamond coatings. The processing was carried out at cutting speeds from 115 to 300 m/min and feed of 0.075 and 0.15 mm/tooth. At the same time, the vibroacoustic signal was recorded in three formats: changes in the RMS value and the amplitude of the acoustic emission in the low-frequency and high-frequency ranges, as well as the parameter Kf, which is the ratio of the RMS amplitudes of the signals in the low-frequency and high-frequency ranges. It is shown that the coating material has a predominant effect on the surface roughness. The minimum roughness value was RA = 0.2 µm for the case of a diamond-coated tool. In addition, the coating improves processing performance by increasing the cutting speed for tools with DLC by 1.3 times and for tools with diamond coating by 1.7 times, provided that the RA increases slightly but does not exceed 0.36 µm. When processed with an uncoated instrument, the mill captures the fiber, bends it and breaks it into bundles, creating grooves. The mechanism of glass fiber destruction by a DLC mill is similar, with the difference that the length of the fragmented fiber sections is noticeably reduced due to reduced friction. The mechanism of cutting fiberglass with a diamond-coated milling cutter is significantly different. There are characteristic scratches on the worn sections of the fiber, and there are no signs of destruction of the composite between the matrix and the fiber. Studies of vibration signals have shown that frequency ranges up to 20 kHz and from 33 to 48 kHz are informative enough to diagnose the fiberglass milling process. The most significant values of the Kf parameter were observed at large amplitudes of low-frequency vibrations, typical for processing with uncoated and DLC milling cutters. The lowest Kf values were obtained using diamond-coated milling cutters. A correlation was found between the values of the Kf parameter and the roughness values of the treated end surface of the fiberglass plate.
Open Access
Article
21 January 2026Study on the Alleviative Effect of Diethyl Aminoethyl Hexanoate (DA-6) on Pepper Seed Germination under Salt Stress
Diethyl aminoethyl hexanoate (DA-6) is a broad-spectrum high-energy plant growth regulator with multiple functions similar to auxin, gibberellin, and cytokinin. Research on crops such as corn, rice, peanuts, flowers, and vegetables has shown that it can increase the activity of plant peroxidase (POD) and nitrate reductase, promote plant cell division and elongation, and facilitate seed germination and seedling growth. This experiment used the seeds of the chili variety “Changxian Tianxia” as research materials. The experiment was conducted by designing DA-6 soaking experiments with different concentration gradients to determine physiological indicators of pepper growth, screen a suitable DA-6 concentration for pepper seed germination, and study the alleviating effect of DA-6 on pepper seed growth under salt stress. The aim is to provide a scientific basis for high-yield cultivation of chili in saline alkali soil. In the seed germination experiment, five DA-6 concentration treatment groups were set up, namely 0, 0.1 mmol/L, 0.5 mmol/L, 1 mmol/L, and 5 mmol/L. Three biological replicates were set up for each treatment group to screen for the most suitable DA-6 concentration for pepper seed germination. The germination and growth effects of pepper seeds under salt stress were then studied using this concentration. The growth physiological indicators were measured to investigate the alleviating effect of aminobutyric acid on pepper seed germination under salt stress. The experimental results showed that the appropriate concentration of aminobutyric acid ester (DA-6) promoted the germination of pepper seeds under salt stress. Under the treatment of soaking seeds in DA-6 at a concentration of 1 mmol/L, the activities of catalase (CAT) and POD increased by 8.6% and 14.6%, respectively, while inhibiting the accumulation of MDA (reducing it by 11.4%), improving the antioxidant effect of plant cell membranes, and enhancing the salt tolerance of pepper seeds. This experiment shows that soaking pepper seeds in 1 mmol/L DA-6 can effectively improve the antioxidant capacity of pepper seeds under salt stress environment, enhance seed germination rate and growth effect, and alleviate the damage caused by salt stress to pepper seedling growth to a certain extent.
Open Access
Article
21 January 2026An Industry 4.0-Based Data Visualization Framework for Improved Manufacturing Data Analysis—A Case Study
The proliferation of Industry 4.0 technologies in manufacturing has created an unprecedented opportunity to leverage Big Data for process optimization and efficiency improvements. However, the sheer volume of data can also lead to critical information being overlooked, potentially hindering productivity and competitiveness. This paper presents a straightforward Industry 4.0-based data visualization framework designed to transform raw manufacturing data into actionable insights. Specifically, this work focuses on the analysis of Overall Equipment Effectiveness (OEE) data. The framework utilizes a practical dashboard tool to enable manufacturers to perform in-depth data analysis and identify areas for improvement in real-time. Such a framework enables prompt intervention when corrective actions are needed, ultimately increasing efficiency and reducing production downtime. The framework was successfully implemented at a tire manufacturing company on a single machine within a short period of time. The results highlighted the effectiveness of data visualization in identifying specific operational losses and informing strategic decision-making. This work emphasizes the critical role of technology and proper policies in leveraging data to optimize production processes and drive continuous improvement in Industry 4.0 environments.
Open Access
Article
20 January 2026Can Global Contract Research Organisations Contribute to Decarbonisation? The Impact of Environmentally Sustainable Business Practice on Scope 1 and 2 Emissions
Carbon emissions of clinical trials have been one of the contributors to global emissions. However, the clinical research industry, particularly contract research organisations (CROs) engaged in trials, has received little attention in the existing literature regarding their carbon footprint. This research examines the sustainable practices implemented by leading global CROs and how these practices influence scope 1 and 2 CO2 emissions. The findings show that increasing the number of sustainability initiatives is insufficient to achieve a measurable reduction in emissions. At the same time, whilst some sustainable practices, such as building upgrades and real estate improvements, lead to a reduction in scope 1 and 2 emissions, others, such as equipment upgrades, are associated with higher emissions. The study, therefore, uncovers a counterintuitive finding—that renewable energy practices showed a positive correlation with emissions. This may be viewed as a paradox, although it serves as a critical warning against measuring sustainability by the quantity of initiatives, rather than their quality or ultimate effect. By assessing the impact of organisational environmental practices on emissions, the study contributes to knowledge by providing a more nuanced understanding of the effectiveness of environmentally sustainable business strategies adopted by CROs.
