Artiles
Article
12 October 2024Production and Destruction of Plant Organic Matter in Bog Ecosystems in the South of Western Siberia
There are still many gaps in studies of the carbon cycle in northern ecosystems. It is challenging also in the context of climate change. This new study focuses on providing the state of the art data on the dynamics of plant organic matter, namely, the live plant biomass (phytomass), the dead biomass (mortmass), the Net Primary Production (NPP), as well as the rate of decomposition of plant organic matter of the major plant species, contributed to peat deposits. The study was conducted via direct in–situ measurements of different fractions of plant organic matter at a few test sites of oligotrophic pine–dwarf shrub–Sphagnum bogs at a wide geographic gradient (from the middle taiga to the forest-steppe regions in Western Siberia) based on an original methodology of measurements developed by the authors. In general, the five groups of plant species were distinguished in terms of productivity and decomposition rates. The study revealed a strong correlation between the net primary production (NPP) and the rate of decomposition of plant organic matter in pristine northern peatlands: an increase in productivity (NPPs) was basically leading to an increase in rates of decomposition in all plant materials collected in bog ecosystems. The study contributes to a global understanding of patterns and main drivers related to basic set of carbon cycle components in the northern wetland (peatland) ecosystems, their diversity and their spatial distribution.
Article
11 October 2024Surfactant Protein-C Regulates Alveolar Type 2 Epithelial Cell Lineages via the CD74 Receptor
Deficiency of surfactant protein-C (SPC) increases susceptibility to lung infections and injury, and suppressed expression of SPC has been associated with the severity of acute respiratory distress syndrome (ARDS). Alveolar type 2 epithelial cells (AT2) are critical for maintenance and repair of the lung. However, the role of the SPC in the regulation of AT2 cell lineage and the underlying mechanisms are not completely understood. This study aimed to investigate the mechanisms by which SPC regulates AT2 lineages. Sftpc−/− mice were used to model the SPC deficiency in ARDS patients. We utilized three-dimensional (3D) organoids to compare AT2 lineage characteristics between wild type (WT) and Sftpc−/− mice by analyzing AT2 proliferation, alveolar type 1 cells (AT1) differentiation and CD74 expression, using colony-formation assay, immunofluorescence, flow cytometry, and immunoblots. The results showed that Sftpc−/− mice demonstrated a reduced AT2 cell population. Influenza A virus subtype H1N1 (H1N1) infected Sftpc−/− mice demonstrated reduced AT2 proliferation and AT1 differentiation. Western blot indicated elevated levels of CD74 protein in AT2 cells of Sftpc−/− mice. Colony-forming efficiency was significantly attenuated in AT2 cells isolated from Sftpc−/− mice compared to the WT controls. Podoplanin (PDPN, a marker of AT1 cells) expression and transient cell count significantly increased in Sftpc−/− organoids. Moreover, siRNA-mediated gene silencing of CD74 in AT2 cells significantly increased AT2 proliferation and AT1 differentiation in Sftpc−/− organoids. This study suggests that SPC regulates AT2 lineage in vitro and in vivo. The SPC might influence AT2 lineage during the lung epithelium repair by activating signaling mechanism involving CD74 receptor.
Perspective
10 October 2024Conceptual Design of Aerostat-Based Autonomous Docking and Battery Swapping System for Extended Airborne Operation
In response to the ever-growing global demand for Unmanned Aerial Vehicles, efficient battery solutions have become vital. This paper proposes a design and concept of an Autonomous Mid Air Battery Swapping System for Vertical Take-Off and Landing Unmanned Aerial Vehicles. The proposed design integrates Aerial Mechatronics, Lighter than Air Systems, and Digital Modelling by leveraging the innovative concept of aerostats for battery swapping. This adaptive and effective technology paves the way for the next generation of autonomous Vertical Take-Off and Landing, ensuring a longer flight time and range. Modern-day technologies have empowered Unmanned Aerial Vehicles to operate autonomously and be remotely controlled, expanding their utility across diverse industries. The enhanced Vertical Take-Off and Landing capabilities include the ability to dock on an aerostat-mounted system, facilitating seamless battery swapping without human intervention and ensuring extended flight duration and operational flexibility. These advancements promise to broaden the applications of Unmanned Aerial Vehicles across various industries.
Review
09 October 2024A Review of Multi-Domain Urban Energy Modelling Data
Urban energy models (UEMs) simulate energy use at the urban scale and are used to inform urban planning, policy development, infrastructure development, and digital twin monitoring and forecasting. Recent technological improvements have spurred interest in large, multi-domain UEMs, which analyse multiple interconnected parts of these energy systems, such as geography, transport, and buildings. Reviews have focussed on single domains or aspects of UEM data. However, multi-domain UEMs require detailed multi-domain data inputs to provide accurate results. This paper provides a comprehensive review of data requirements and a repository of data-specific information for researchers, including data formats, sources, acquisition methods, bridging methods, and challenges. The review was conducted using academic search engines and the authors’ direct research experience. Domains are characterised by Climate, Geographic, Building, Transportation, Demographics, Energy Networks and Consumption, and Distributed Energy Resources. Additionally, challenges common to multiple sectors are identified, and methods for addressing these are proposed. The paper concludes with a series of recommendations drawing from the general and sector-specific challenges. Overall, a large amount of data exists, but their use by urban energy modellers is limited due to lack of coordination and standardisation, and concerns over privacy and commercial interests. Coordinated public effort is required to overcome these limitations and improve the results of UEMs in the future.
Communication
08 October 2024Alterations of T Cell Subsets Associated with Sickle Cell Trait
Sickle cell trait (SCT) has been associated with alterations in various immune-related laboratory parameters including lower circulating lymphocyte counts. To further characterize the impact of SCT on the immune system, we performed flow cytometry of monocyte and lymphocyte immune cell subsets from peripheral blood mononuclear cells collected in a large, community-based cohort of SCT-positive (n = 68) and SCT-negative (n = 959) Black adults. SCT was significantly associated with lower proportions of CD8+ and CD4+ T cell subsets that include senescent-like markers of repeated immune system challenges. These immune alterations could have potential implications for the susceptibility of individuals with SCT to various infectious diseases.
Review
30 September 2024Ecological Civilizations—A Development Narrative for the Global South?
We explore possibilities for the ecological civilization imaginary of China to become a sustainable development narrative shared by a growing number of GS nations. We first highlight the influence GS countries had on the evolution of the concept of sustainable development. GS nations’ interest in retaining economic development options, including energy and materials needed for industrialization and economic expansion, will increasingly contradict global environmentalist narratives of the latter half of the 20th century. The adaptation of GS nations to previously untested energy and material futures will depend on experimentation and learning from initiatives primarily designed and implemented by GS governments at the national, provincial, and local levels. If China succeeds in demonstrating practical examples of ecological civilization construction, it will stimulate other GS countries to learn and adapt lessons to suit their own needs. Multi-country arrangements that China has created could serve as forums to refine the ecological civilization narrative as a development alternative to the dualist conservation vs development thinking and practice of the latter half of the 20th century.
Review
30 September 2024The Jerusalem Megalithic Rock Calendar Is an Identical Representation to That Found in Lanzarote Island (Canary Islands, Spain)
We have recently found that a megalithic basaltic rock lunisolar calendar in Lanzarote, Canary Islands (“Quesera or Cheeseboard” of Zonzamas) has almost a twin monument in Jerusalem (Al Quds in Arab). These two unique monuments are on the West and East sides of the Sahara Desert and support the hypothesis of a common “Green” Saharan culture and a later migration of people towards the Atlantic, Mediterranean, Middle East and other areas when desiccation started after 10,000 years BC, thus spreading culture and genes. Traces of this culture can still be found in Iberian rock inscriptions on the Canary Islands and in the Sahara Desert, particularly at Tim-Missaou in Algeria.This is concordant with Usko-Mediterranean languages (Basque and Berber are related and also with Iberian and Etruscan), genetics and other common anthropological traits. In this paper, we analyse the Al Quds-Jerusalem megalithic monument as representing a solar calendar of Egyptian-type (365 days in 1 year) and show how it could be identical to the Lanzarote megalithic calendar (“Quesera or Cheeseboard” of Zonzamas). Both monuments,each crest/channel, are coincidental in each solar month assignment in both Lanzarote and Jerusalem rock calendars representation. Jerusalem’s megalithic calendar was built at least 900 years BC, when it fell out of use. Therefore, it can be assumed that the Lanzarote megalithic calendar was constructed around a similar time, meaning an undetermined period over 2800 years ago.
Article
30 September 2024Synthetic Biology in Nigeria: The Level of Awareness amongst Stakeholders
Synthetic biology, an emerging field at the intersection of biotechnology and engineering, has seen a global surge in application and awareness, necessitating a comprehensive understanding of its safe potentials to drive the bio-economy. This study aimed to assess the awareness and perceptions of synthetic biology among Nigerian biosciences stakeholders, including researchers, academicians, policymakers and students. The study employed a purposive online survey targeting diverse bioscience individuals and groups across Nigeria’s six geopolitical zones. The study received 107 responses from balanced gender representation with majority within the age group of 31–45 years old. The findings revealed a significant knowledge gap, with only 27.1% of respondents familiar with synthetic biology and 23.4% entirely unaware of it. Most respondents associated synthetic biology with biotechnology or genetic engineering and identified its applications to be in agriculture, medicine, environmental sustainability and research. Despite recognizing its benefits, many expressed concerns about safety, ethics, and regulation; notably, 43.9% of the respondents had concerns about synthetic biology with primary focus on safety and ethical implications. As regards the regulation of synthetic biology, the study showed that 80.4% of the respondents supported the need for synthetic biology regulation with few of the respondents (16.8%) aware of existing agency mandated to regulate synthetic biology. The respondents provided valuable insights into the various ways synthetic biology can be advanced in Nigeria which include increased awareness and capacity building, engagement through social media platforms, integration into education curricula and increased funding and investment in the research. The overall sentiment towards synthetic biology was positive, with 81.3% supporting its practice and 76.6% recognizing its positive global impact. However, a significant portion of respondents remained undecided. This study concludes that there is substantial gap in the knowledge of synthetic biology among bioscience stakeholders in Nigeria and the need for a heightened advocacy including continuous conferences and symposiums for the Nigeria bioscience community on the global potentials, concerns and regulation of synthetic biology. This will foster the acceptance of safe and responsible synthetic biology in Nigeria, thereby contributing to the broader national bio-economy development.
Article
29 September 2024Reactions and Phase Transformations at Sintering of Cubic Boron Nitride Based Materials
Superhard cubic boron nitride (cBN) cutting materials with different contents of cBN were investigated. The compositions of cBN-based materials included ceramic and metallic binders. The sintering of materials was performed by high-temperature hot pressing (HPHT) six-anvil apparatus at pressure 4.5 GPa and temperatures 1400–1450 °C. The process of compaction and processing of superhard cBN materials is followed by numerous chemical reactions. The chemical reactions are very important in compaction and sintering. The volume transformations during chemical reactions affect the shrinkage of the materials and may also impact the residual porosity of the finished products. The adhesion between the grains also depends on these chemical reactions. The research analyzed the volume transformations of various reactions during HPHT sintering of cBN materials, which may play a significant role in forming their structure and properties.
Article
27 September 2024Responsibility as Method—A Model for Operationalizing Ethical Reflection in the Sciences
In this article, we show why the growing significance of ethics entails that the call for ethical evaluations is no longer just a specific issue for the particular discipline of academic ethics but a challenge for all academic researchers. Therefore, complex theoretical approaches must be put into practice, and the relationship between ethics and other scientific fields must be clarified. Hence, this essay shows how these requirements can be fulfilled and how to cope with the complexity of ethical consideration on a practical level. We aim to operationalize responsibility as a method. In order to achieve this, basic criteria of practical ethical reflection are elaborated. As a result, we suggest an extended ethical matrix covering the entire research process using a step-by-step model. Our ethical matrix is designed to help researchers reflect and make judgments on moral and ethical issues, enabling them to find their own solutions to these challenges without providing a formal guideline for moral decision-making.
