Differences in Flood Quantiles Estimate of Disturbed and Undisturbed Watersheds in the United States

Nonstationarity due to climate variation and anthropogenic disturbances has altered high flow regimes. However, the extent of change has not been evaluated for undisturbed versus disturbed watersheds. This article aimed to determine how partitioning watersheds into undisturbed and disturbed categories can improve the performance of probability distributions for flood analysis throughout the United States. We utilized peak flow information for 26 reference (undisturbed) and 78 nonreference (disturbed) watersheds with drainage areas ranging from 135 to 42,367 km² and record lengths of 100 to 140 years. Results indicated that flood quantile estimates of the Log Pearson Type III (LP3) distribution were likely being overestimated for return periods of 2 to 10 years, while flood estimates of 50 years and higher might be underestimated. In contrast, the Generalized Extreme Value (GEV) distribution outperformed LP3 in estimating floods with return periods of 50 years or more. These findings enhance flood frequency analysis and forecasting under nonstationary conditions.

Marine Energy, the Future Practical Route to Carbon Neutrality—Foreword: Navigating the Voyage of Marine Energy Research

Hazardous Gas Monitoring with IoT Enabled Drone in Underground Tunnels and Cavities

Considering the healthiness of the atmosphere in mining activities (e.g., tunnelling), two of the most important parameters to be monitored are the concentration of oxygen and the presence of harmful gases such as CO₂. Traditional methods for their measurement are fixed platforms and portable gas detectors carried by miners; they are incapable of recognizing sudden or short-term pollution events or correctly accounting for the spatial scarcity of gases. A UAV (Unmanned Aerial Vehicle) device capable of guaranteeing the measurement and continuous monitoring of concentrations has been designed. By using innovative technologies, it promotes digitization in the mining sector. This approach replaces current methods that, while effective at detecting and measuring environmental parameters, are slow, routine, and heavily reliant on human input. It saves productive expenses in the sector since it reduces costs compared to hiring a field technician for activities such as analysis of environmental conditions. This saving is about 110 euros daily, representing a 32% saving per working day for each mining technical responsible for environmental control. It also obtains a 3D spatial distribution of contaminants, a high sample resolution and a high sample resolution.. It reduces inspection time in mining works and the data collection time by more than 50%. The ECODRONE project constitutes a contribution to the MINE THE GAP challenge is a project financed with European funds whose line of desire aims to combine the innovation and development of SMEs or business groups from different regions of the mining, raw materials and materials sector. This program is aimed at strengthening the existing value chains and developing new industrial ones while designing new procedures, automated technologies, information and communication flows, which increase efficiency in the consumption of resources. All of the above implies integration with a circular economy and respect for European and global efficiency policies aimed at sustainability, industrial modernization, human health and the environment.

Application of Synthetic Biology to the Biosynthesis of Polyketides

Polyketides (PKs) are a large class of secondary metabolites produced by microorganisms and plants, characterized by highly diverse structures and broad biological activities. They have wide market and application prospects in medicine, agriculture, and the food industry. The complex chemical structures and multiple steps of natural polyketides result in yield that cannot be met by purely synthetic methods. With the development of synthetic biology, a number of novel technologies and synthetic strategies have been developed for the efficient synthesis of polyketides. This paper first introduces polyketides from different sources and classifications, then the reconstruction of biosynthetic pathways is described using a “bottom-up” synthetic biology approach. Through methods such as enhancing precursors, relieving feedback inhibition, and dynamic regulation, the efficient production of polyketides is achieved. Finally, the challenges faced by polyketides research and future development directions are discussed.

Comparative Study: Biodegradable Chelating Agents vs. Aqua Regia for Extraction of Indispensable Elements from Pyrite Ore of Bagrot, Gilgit Baltistan

This study investigates the optimization of metal extraction from Bagrot pyrite ore, with a focus on gold recovery. Initial characterization using X-ray fluorescence (XRF) provided a comprehensive elemental profile of the ore. Fire assaying was employed to establish a baseline gold concentration. Systematic leaching experiments were conducted, varying parameters such as reaction time, temperature, and stirring speed, and the results were analyzed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Among the chelating agents tested Ethylenediamine N-N′ disuccinic acid (EDDS), Ethylenediaminetetraacetic acid (EDTA), and Diethylenetriaminepentaacetic acid (DTPA) only limited efficacy in gold extraction was observed. In contrast, ammonium thiosulfate demonstrated substantial potential for effective gold recovery. Mercaptobenzothiazole (MBT) and N,N-Dimethylglycine (DMG) were determined to be ineffective for metal leaching under the tested conditions. This research highlights the critical role of reagent selection and parameter optimization in enhancing the efficiency and sustainability of gold extraction processes, positioning ammonium thiosulfate as a promising alternative to traditional cyanide-based methods.

Interstage Growth Failure May Adversely Affect Clinical Outcomes in Hypoplastic Left Heart Syndrome: Results from a Single Center Ten-Year Review

Purpose: Infants with Hypoplastic left heart syndrome (HLHS) are particularly vulnerable during their interstage period which is the time between Stage 1 palliation (S1P) and Stage 2 palliation (S2P). Interstage Monitoring Program (IMP) was established to reduce mortality after discharge following S1P and consists of close monitoring of certain key parameters including hypoxia, growth failure and occurrence of major events. As somatic growth is a potentially modifiable determinant of interstage mortality, we aimed to study the incidence and risk factors of growth failure among infants followed by our IMP over the last 10 years. Methods: We included HLHS infants who were enrolled in institutional IMP following discharge after S1P from May 2009 to April 2019. Growth failure was defined as per the NPC-QIC criterion as failure to achieve target interstage weight of 20–30 g per day and risk factors for growth failure were explored. Results: A total of 87 patients were enrolled during the study period, of whom 72 (n = 83%) underwent S2P. About one third (23 patients) failed to achieve the target growth rate despite close monitoring through a robust IMP. Growth failure significantly delayed the time to more stable S2P circulation (median IS duration: 131 days vs 86 days, p = 0.002). Patients with growth failure had a significantly higher incidence of death/transplant prior to Stage 3 (Fontan) completion (39% vs 16%, p = 0.03). Interstage growth failure was significantly associated with a “Hybrid-type” of repair during S1P (p = 0.03); and with the need for opioids at discharge (p = 0.04). Conclusion: This study highlights that growth failure is common in HLHS patients, despite active intervention through an IMP program. These patients appear to have significantly worse transplant-free survival rates compared to their counterparts. Pre-interstage risk factors including use of opioids may need to be addressed to assist adequate somatic growth during interstage.

Rural Nonfarm Enterprise and Its Impact on Household Livelihood in Ethiopia: Evidence from Gurage Zone

In Ethiopia, until recently, less attention has been given to rural entrepreneurship, while the rural economy has accounted for the lion’s share of employment, export earnings, and national income. This study scrutinized the factors influencing rural household participation in nonfarm enterprise and its impact on household livelihood in the Gurage zone. Data was collected from 352 households using questionnaires, and Key-Informant Interviews and Focus Group Discussions were used. The factors influencing household participation in nonfarm enterprises were estimated using a logit model, while Propensity Score Matching (PSM) was employed to assess the impact on household livelihoods. Women, single-headed households, households with larger family sizes, and households with secondary and primary education are more likely to participate in nonfarm enterprises. In addition, access to extension services, training, market, transport, credit, and being a member of cooperatives have increased the probability of household participation in nonfarm enterprise. Participation in nonfarm enterprises improved the livelihood of rural households. Rural nonfarm enterprises should be integrated into national policy as a means of economic empowerment, focusing on creating employment opportunities for women and youth and reducing poverty. Rural infrastructure expansion, access to credit, and entrepreneurship training should be prioritized and the sector should be enhanced as an alternative livelihood strategy.

Land-Tenure Shifts in the Maa Landscapes, Kenya, and the Impacts on Social-Cultural Relations, Structural Power and Social Economic Differentiation

In recent years, the expansive pastoralist landscapes in southern Kenya have undergone rapid transformation, the key being a change in the land-tenure system from communal to individual ownership. However, little is known about the complexities influencing these changes and how the changes impact the local people. This study employed qualitative inductive approaches and ethnographic methods, such as participant observation and in-depth interviews. It examined how local and international formal and informal institutions have impacted land tenure changes among the Maa pastoralists living near Chyulu and Tsavo-West national parks. Despite the expected benefits of individual land ownership, the changes have not addressed significant social barriers. These include norms and power structures that disadvantage the poor in the community, as well as women and youth within households. People with higher levels of poverty and fewer or no political connections are marginalized during land adjudication at the community level. At the same time, traditions and customs deny women and youth entitlement to property at the household level. Such groups thus experience land privatisation differently. This article argues that expropriation and unequal abilities to control, access and benefit from land profoundly impact social differentiation among pastoralists. Further, the article illuminates a more-than-human achievement, with wildlife shaping people’s lives through conservation-induced land expropriation, and a more-than-human vulnerability that livestock and wildlife face in the wake of land fragmentation and fencing that restrict their free movement. The article contributes to more significant debates on pastoralist land tenure, property relations, ongoing changes in land control processes, and more-than-human achievements and vulnerabilities.

Airway Serous Cells: A Comparative Study of Spatial Distribution and Abundance among Species

The conducting airways of the respiratory system play a crucial role in filtering, humidifying, and directing air into the lungs. Among the specialized cell types within these airways, airway serous cells are notable for their secretion of watery, protein-rich fluids and enzymes, which contribute to maintaining airway surface liquid homeostasis and defending against pathogens. However, the distribution and abundance of serous cells across different species in the conducting airways remain poorly understood. In this study, we addressed this gap by investigating the spatial distribution of the airway serous cell-specific marker BPI fold containing family A member 1 (BPIFA1) in humans, pigs, and mice. Our findings demonstrate significant variations in the distribution and abundance of serous cells among these species, potentially reflecting their different respiratory anatomy and evolutionary adaptations to diverse environmental challenges and respiratory demands. In humans and pigs, airway serous cells are predominantly found in the submucosal glands of the trachea and segmental bronchi, frequently overlapping with lysozyme-positive secretory cells. In contrast, rodents like mice exhibit a distinct pattern where serous cells are scarce in submucosal glands. Instead, rodent serous cells are primarily located at the epithelial surface from the trachea to the main bronchi, where many co-express the Club cell-specific protein SCGB1A1. The abundance of serous cells diminishes progressively in the intrapulmonary airways. Given that rodent models are widely utilized in respiratory research, understanding anatomical and cellular differences in airway serous cells is critical for interpreting experimental outcomes and translating findings to human respiratory diseases and therapeutic strategies. This comparative analysis enhances our understanding of airway biology across species and informs the selection and interpretation of animal models in respiratory studies.

Evaluation of a Present-Day Thermal Activity on the Constitutive Minerals of a Granite and of Its Impact on the Whole-Rock Sealing Potentials

Mineralogical and chemical analyses of the major constitutive minerals from granite des Crêtes collected near the thermal site of Plombières-les-Bains (Vosges Mountains, eastern France) clearly show that recently circulating thermal waters up to 90 °C do not impact them. Even the constitutive minerals smaller than 2 microns are not affected. As a result, all minerals reflect the entire complex tectonic-thermal history of the granitic massif rather than just the recent thermal impact. Only the open faults and natural drains contain calcite from recent thermal waters. This is confirmed by similar calcite deposits with the same elemental contents sampled in the pipes of thermal installations. As a complementary conclusion, storage of containers of nuclear waste that diffuse an overall temperature up to 100 °C will not alter the potential sealing properties of a plutonic host massif, of course, without any recent thermal drainage that could potentially spread radioactive waste. This conclusion was already obtained on a moderately faulted sedimentary environment after a one-year in-situ heating experiment at about 100 °C. Calcium is a key indicator of low thermal impact. After an initial decrease, its levels rose significantly in the most "altered" granite samples, inducing calcite precipitation, even in the water pipes at the thermal site. The negligible impact of a hydro-thermal activity at a maximum of about 100 °C in a granitic material represents, indeed, a piece of useful information, as deep sites for nuclear waste in plutonic host rocks appear to act, also, as potential isolated host systems.