Pacific Island Countries (PICs) face some of the most severe health risks from climate change, with associated mental health impacts that remain under-recognized. This scoping review synthesizes peer-reviewed literature published by February 2025 to examine the mental health consequences of exposure to climate-related hazards across 22 PICs. The search identified 193 studies, 19 of which were included in the review. Most studies employed qualitative or mixed methods, focusing on storms, droughts, sea-level rise, planned relocation, and environmental changes. Reported mental health outcomes included increased depression, anxiety, grief, and distress, often linked to direct exposure and secondary effects such as displacement, resource insecurity, and social disruption. Risk and protective factors were identified, emphasizing broader social, cultural, spiritual, and environmental influences that mediate the relationships between climate-sensitive hazard exposures and mental health outcomes in PICs. Cultural mediators such as traditional knowledge, land connection, and community cohesion shaped both vulnerability and resilience. Common coping strategies included relocation, community-based support, and leadership-driven actions. However, access to mental healthcare remained limited due to a shortage of trained professionals, stigma, and preference for traditional healing methods. To address these challenges, it is essential to integrate mental health into national public health frameworks, enhance disaster preparedness, increase access to mental health services, and conduct context-specific research.
Lung cancer represents a significant burden on global health, necessitating the need for new and effective treatment strategies that expand our current therapeutic repertoire. Immunotherapy, namely immune checkpoint blockade (ICB), has revolutionized lung cancer therapy over the last decade by invigorating anti-tumor T cell responses to prolong survival and quality of life. However, not all patients benefit from ICB, emphasizing the need for novel immunotherapeutic strategies that engage other immune functionalities to offer synergy with already available therapies. There has been a longstanding interest in deploying lung cancer vaccines to generate or enhance tumor antigen-specific T cell responses for greater tumor control. Thus far, success has been limited to early-stage clinical trials, where safety, generation of antigen-specific T cell responses in blood sampling, and some patient benefits have been established. Moving forward, the establishment of widespread clinical success in large-scale trials is a necessity to bring lung cancer vaccines into the therapeutic arsenal. In this review, we examine the logic and mechanisms behind therapeutic lung cancer vaccines, before critically and iteratively examining past and current attempts in lung cancer vaccinology. We also look at early pre-clinical studies and outline the future for therapeutic lung cancer vaccines.
Bacillus methanolicus MGA3 is a methylotrophic bacterium with a high potential as a production host in the bioeconomy, particularly with methanol as a feedstock. This review presents the recent acceleration in strain engineering technologies through advances in transformation efficiency, the development of CRISPR/Cas9-based genome editing, and the application of genome-scale models (GSMs) for strain design. The generation of novel genetic tools broadens the biotechnological potential of this thermophilic methylotroph. B. methanolicus is a facultative methylotroph and apart from methanol it can grow on mannitol, arabitol and glucose, and was engineered for starch and xylose utilisation. Here, the central carbon metabolism of B. methanolicus for various native and non-native carbon sources is described, with an emphasis on methanol metabolism. With its expanding product portfolio, B. methanolicus demonstrates its potential as a microbial cell factory for the production of tricarboxylic acid(TCA) cycle and ribulose monophosphate (RuMP) cycle intermediates and their derivatives. Beyond small chemicals, B. methanolicus is both a valuable source of novel thermostable proteins and a host for the production of heterologous proteins, enabled by advances in genetic tools and cultivation methods. Continued progress in understanding its physiology and refining its genetic toolbox will be decisive in transforming B. methanolicus from a promising candidate into a fully established industrial workhorse for sustainable methanol-based biomanufacturing.
This study investigates the thermal performance and freshwater productivity of a passive single-slope solar still under four distinct configurations, aimed at enhancing distillation efficiency using low-cost modifications. The experiments were conducted in Tabuk, Saudi Arabia (28°23′50″ N, 36°34′44″ E), a region characterized by high solar irradiance ranging from 847 to 943 W/m2. The baseline system, constructed with a stainless-steel basin and inclined transparent glass cover, served as the control, achieving a cumulative distillate yield of 3.237 kg/m2/day and a thermal efficiency of 36.27%. Subsequent modifications included the addition of external reflective mirrors (Experiment 2), aluminum foil foam insulation (Experiment 3), and internal enhancements with side glass panels and internal aluminum mirrors (Experiment 4). Results demonstrated that the external mirror modification improved the distillate yield by 16% to 3.757 kg/m2/day, with a corresponding efficiency of 41.66%. However, insulation under dusty conditions led to a reduced yield of 2.000 kg/m2 and an efficiency of 25.18%, highlighting the critical influence of solar transmittance. The most notable improvement was recorded in the fourth configuration, which combined internal reflective elements and transparent side panels, resulting in a maximum yield of 4.979 kg/m2/day and thermal efficiency of 56.45%. These findings confirm that optical and thermal design enhancements can significantly augment the performance of passive solar stills, especially under high-irradiance, clear-sky conditions. The proposed modifications are low-cost, scalable, and suitable for implementation in remote and arid regions facing freshwater scarcity. This study offers valuable insights into the systematic optimization of solar distillation systems to improve sustainable water production.
Heart failure (HF) is the leading cause of mortality in adults with congenital heart disease (ACHD), including patients with systemic right ventricles, such as those with dextro-transposition of the great arteries with an atrial switch (DTGA-AS). With more ACHD patients surviving well into adulthood, there is an increase in advanced heart failure (HF) and pulmonary hypertension (PH), many of whom are being treated with SGLT2-inhibitors (SGLT2-i). However, there is a paucity of data supporting SGLT2-i inhibitor use in the ACHD population and on how they may impact pulmonary artery pressures (PAP). This single center retrospective study aimed to evaluate the impact of SGLT2-i on (PAP) in patients with DTGA-AS. Six patients were studied, all male (mean age 41 [range 38–52] years), with a mean systemic right ventricular ejection fraction of 27% (range 22–32%), with an implanted hemodynamic CardioMEMs monitor data were recorded one month prior to medication start and six months afterwards. Half of the patients had normal PAP, and the addition of SGLT2i did not result in a significant change in PAP in all patients. However, half of the patients demonstrated a trend towards improvement. In conclusion, in this study with a small sample size of DTGA-AS patients, there was no significant reduction in PAP.
